Antioxidant Effect of Naringin Demonstrated through a Bayes' Theorem Driven Multidisciplinary Approach Reveals its Prophylactic Potential as a Dietary Supplement for Ischemic Stroke

Data after Bayesian analysis showing top 100 probable protein targets of Naringin. Bayes' theorem was applied eleven successive times to incorporate various large scale proteomics datasets through likelihood vectors.

Dataset
Gene Symbol Protein Name Initial Probability N2a RNA-Seq
Posterior Probability [P(A│B)]		 N2a Proteome 1
Posterior Probability [P(A│B)]		 N2a Proteome 2
Posterior Probability [P(A│B)]		 N2a Proteome 3
Posterior Probability [P(A│B)]		 N2a Proteome 4
Posterior Probability [P(A│B)]		 N2a Proteome 5
Posterior Probability [P(A│B)]		 N2a Proteome 6
Posterior Probability [P(A│B)]		 OGD Proteome 1
Posterior Probability [P(A│B)]		 OGD Proteome 2
Posterior Probability [P(A│B)]		 OGD Proteome 3
Posterior Probability [P(A│B)]		 OGD Proteome 4
Posterior Probability [P(A│B)]		 ROS-GO
Posterior Probability [P(A│B)]		 Rank
ALDH2 Aldehyde dehydrogenase, mitochondrial 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.02111 0.02603 0.02580 0.02211 0.02980 0.04300 0.04284 1
ACAT1 Sterol O-acyltransferase 1 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.02111 0.02603 0.02580 0.02211 0.02980 0.04300 0.04284 1
CTSB Cathepsin B 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.02111 0.02603 0.02580 0.02211 0.02980 0.04300 0.04284 1
FASN Fatty acid synthase 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.02111 0.02603 0.02580 0.02211 0.02980 0.04300 0.04284 1
LDHA Lactate dehydrogenase A 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.02111 0.02603 0.02580 0.02211 0.02980 0.04300 0.04284 1
PTGS1 Prostaglandin-endoperoxide synthase 1 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.02111 0.02603 0.02580 0.02764 0.02661 0.03839 0.03825 6
CTSD Cathepsin D 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.02111 0.02603 0.02580 0.02764 0.02661 0.03839 0.03825 6
LGALS1 Galectin 1 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.02111 0.02603 0.02580 0.02211 0.01703 0.02457 0.02448 8
TARDBP TAR DNA binding protein 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.02111 0.02603 0.02580 0.02211 0.01703 0.02457 0.02448 8
CDK1 Cyclin dependent kinase 1 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.02111 0.02603 0.02580 0.02211 0.02980 0.02389 0.02380 10
UBE2N Ubiquitin conjugating enzyme E2 N 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.01111 0.01370 0.01358 0.01164 0.01569 0.02263 0.02255 11
OGDH Oxoglutarate dehydrogenase 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.02111 0.02603 0.02580 0.02764 0.02661 0.02133 0.02125 12
SOD2 Superoxide dismutase [Mn], mitochondrial 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.02111 0.02603 0.02580 0.02764 0.02661 0.02133 0.02125 12
LARS Leucyl-trna synthetase 1 0.00346 0.00406 0.00550 0.00891 0.01198 0.00732 0.01111 0.01370 0.01358 0.01455 0.01401 0.02020 0.02013 14
CDK4 Cyclin dependent kinase 4 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.01111 0.01370 0.01901 0.02036 0.01961 0.01571 0.01566 15
GSR Glutathione-disulfide reductase 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.02111 0.02603 0.02580 0.02211 0.01703 0.01365 0.01360 16
IDH1 Isocitrate dehydrogenase (NADP(+)) 1 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.02111 0.02603 0.02580 0.02211 0.01703 0.01365 0.01360 16
TXNRD1 Thioredoxin reductase 1 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.01111 0.01370 0.01358 0.01164 0.01569 0.01257 0.01253 18
VARS Valyl-trna synthetase 1 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.02111 0.01370 0.01358 0.01455 0.01401 0.01122 0.01118 19
SLC29A1 Solute carrier family 29 member 1 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.01111 0.01370 0.01358 0.01455 0.01401 0.01122 0.01118 19
CASP3 Caspase 3 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.01111 0.01370 0.01358 0.01455 0.01401 0.01122 0.01118 19
CASP7 Caspase 7 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.01111 0.01370 0.01358 0.01455 0.01401 0.01122 0.01118 19
DHFR Dihydrofolate reductase 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.01111 0.01370 0.01358 0.01455 0.01401 0.01122 0.01118 19
DKK1 Dickkopf WNT signaling pathway inhibitor 1 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.01111 0.01370 0.01358 0.01455 0.01401 0.01122 0.01118 19
GCLC Glutamate-cysteine ligase catalytic subunit 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.01111 0.01370 0.01358 0.01455 0.01401 0.01122 0.01118 19
MAPK1 Mitogen-activated protein kinase 1 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.01111 0.01370 0.01358 0.01455 0.01401 0.01122 0.01118 19
GSK3B Glycogen synthase kinase 3 beta 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.01111 0.01370 0.01358 0.01455 0.01401 0.01122 0.01118 19
ACACA Acetyl-coa carboxylase alpha 0.00346 0.00406 0.00550 0.00891 0.01198 0.00732 0.01111 0.01370 0.01358 0.01455 0.01401 0.01122 0.01118 19
ABCC1 ATP binding cassette subfamily C member 1 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.01111 0.01370 0.01358 0.01455 0.01401 0.01122 0.01118 19
PTPN1 Protein tyrosine phosphatase non-receptor type 1 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.01111 0.01370 0.01358 0.01455 0.01401 0.01122 0.01118 19
MTOR Mechanistic target of rapamycin kinase 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.01111 0.01370 0.01358 0.01455 0.01401 0.01122 0.01118 19
CPT1A Carnitine palmitoyltransferase 1A 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.01111 0.01370 0.01358 0.01455 0.01401 0.01122 0.01118 19
EIF4A1 Eukaryotic translation initiation factor 4A1 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00564 0.00760 0.01097 0.01093 33
CDK2 Cyclin dependent kinase 2 0.00346 0.00406 0.00550 0.00891 0.00630 0.00732 0.00585 0.00721 0.00715 0.00766 0.00737 0.01063 0.01059 34
MAPK3 Mitogen-activated protein kinase 3 0.00346 0.00406 0.00550 0.00891 0.00630 0.00732 0.00585 0.00721 0.00715 0.00766 0.00737 0.01063 0.01059 34
CAT Carnitine O-acetyltransferase 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00721 0.00715 0.00766 0.00737 0.01063 0.01059 34
CBR1 Carbonyl reductase 1 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.01111 0.01370 0.01358 0.01164 0.00896 0.00718 0.01002 37
PARP1 Poly(ADP-ribose) polymerase 1 0.00346 0.00406 0.00550 0.00891 0.01198 0.01390 0.01111 0.01370 0.01358 0.01164 0.00896 0.00718 0.00716 38
BAX BCL2 associated X, apoptosis regulator 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.01111 0.01370 0.01358 0.01164 0.00896 0.00718 0.00716 38
CBX1 Chromobox 1 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00721 0.00715 0.00612 0.00472 0.00681 0.00678 40
GOT1 Golgi transport 1B 0.00346 0.00406 0.00550 0.00891 0.00630 0.00732 0.00585 0.00721 0.00715 0.00766 0.00737 0.00591 0.00589 41
GUSB Glucuronidase beta 0.00346 0.00406 0.00550 0.00891 0.00630 0.00732 0.00585 0.00721 0.00715 0.00766 0.00737 0.00591 0.00589 41
ADAM17 ADAM metallopeptidase domain 17 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.01111 0.00721 0.00715 0.00766 0.00737 0.00591 0.00589 41
FHIT Fragile histidine triad diadenosine triphosphatase 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00721 0.00715 0.00766 0.00737 0.00591 0.00589 41
PDE5A Phosphodiesterase 5A 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00721 0.00715 0.00766 0.00737 0.00591 0.00589 41
RELA RELA proto-oncogene, NF-kb subunit 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00721 0.00715 0.00766 0.00737 0.00591 0.00589 41
STAT3 Signal transducer and activator of transcription 3 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00721 0.00715 0.00766 0.00737 0.00591 0.00589 41
FADD Fas associated via death domain 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00721 0.00715 0.00766 0.00737 0.00591 0.00589 41
MAPK8 Mitogen-activated protein kinase 8 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00585 0.00721 0.00715 0.00766 0.00737 0.00591 0.00589 41
HMOX1 Heme oxygenase 1 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00527 0.00564 0.00543 0.00435 0.00434 50
ACOX1 Acyl-coa oxidase 1 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00277 0.00297 0.00286 0.00412 0.00411 51
AKR1B1 Aldo-keto reductase family 1 member B 0.00346 0.00406 0.00289 0.00247 0.00332 0.00385 0.00308 0.00200 0.00198 0.00170 0.00229 0.00330 0.00329 52
GSTP1 Glutathione S-transferase pi 1 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
PTPN2 Protein tyrosine phosphatase non-receptor type 2 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
TDP1 Tyrosyl-DNA phosphodiesterase 1 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
IMPDH1 Inosine monophosphate dehydrogenase 1 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
NADK NAD kinase 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
CASP2 Caspase 2 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
POLB DNA polymerase gamma 2, accessory subunit 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
AKT1 AKT serine/threonine kinase 1 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
ATF2 Glial cell derived neurotrophic factor 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
CASP9 Caspase 9 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
GPX1 Glutathione peroxidase 1 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
HMGCR 3-hydroxy-3-methylglutaryl-coa reductase 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
IRS1 Insulin receptor substrate 1 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
JUN Jun proto-oncogene, AP-1 transcription factor subunit 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
PRKCD Protein kinase C delta 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
RAF1 Ribonuclease A family member 3 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
EHMT2 Euchromatic histone lysine methyltransferase 2 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
USP1 Ubiquitin specific peptidase 1 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
GMNN Geminin DNA replication inhibitor 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
NFKB1 Nuclear factor kappa B subunit 1 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
PIK3R1 Phosphoinositide-3-kinase regulatory subunit 1 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
SIRT1 Sirtuin 1 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
SREBF1 Sterol regulatory element binding transcription factor 1 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
PYGL Glycogen phosphorylase L 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
ACE Angiotensin I converting enzyme 0.00346 0.00406 0.00550 0.00469 0.00630 0.00732 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
LGALS8 Galectin 8 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
CHAC2 Chac glutathione specific gamma-glutamylcyclotransferase 2 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00585 0.00380 0.00376 0.00403 0.00388 0.00311 0.00310 53
PTGR1 Prostaglandin reductase 1 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00295 0.00293 80
CTNNB1 Catenin beta 1 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00295 0.00293 80
COL1A1 Collagen type I alpha 1 chain 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00277 0.00297 0.00286 0.00229 0.00228 82
CCND1 Cyclin D1 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00228 82
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.00346 0.00214 0.00152 0.00247 0.00332 0.00385 0.00308 0.00380 0.00376 0.00322 0.00248 0.00199 0.00198 84
CASP6 Caspase 6 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00163 85
CASP8 Caspase 8 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00163 85
ALB Fas binding factor 1 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00163 85
ACHE Acetylcholinesterase 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00163 85
ADA Adenosine deaminase 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00163 85
BAD BCL2 associated agonist of cell death 0.00346 0.00406 0.00289 0.00247 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00163 85
CDKN1A Cyclin dependent kinase inhibitor 1A 0.00346 0.00406 0.00289 0.00247 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00163 85
EGFR Epidermal growth factor receptor 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00163 85
MAPK10 Mitogen-activated protein kinase 10 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00163 85
MAPK9 Mitogen-activated protein kinase 9 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00163 85
NFKBIA NFKB inhibitor alpha 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00163 85
RPS6KB1 Ribosomal protein S6 kinase B1 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00163 85
TP53 Tumor protein p53 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00163 85
NQO1 NAD(P)H quinone dehydrogenase 1 0.00346 0.00406 0.00550 0.00469 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00163 85
F2 Transcription termination factor 2 0.00346 0.00406 0.00289 0.00247 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00163 85
FAS Fatty acid synthase 0.00346 0.00406 0.00289 0.00247 0.00332 0.00385 0.00308 0.00200 0.00198 0.00212 0.00204 0.00164 0.00163 85
TGFB1 Transforming growth factor beta 1 0.00346 0.00406 0.00289 0.00247 0.00175 0.00107 0.00162 0.00105 0.00104 0.00112 0.00107 0.00086 0.00086 101
Gene Symbol Protein Name Initial Probability N2a RNA-Seq
Posterior Probability [P(A│B)]		 N2a Proteome 1
Posterior Probability [P(A│B)]		 N2a Proteome 2
Posterior Probability [P(A│B)]		 N2a Proteome 3
Posterior Probability [P(A│B)]		 N2a Proteome 4
Posterior Probability [P(A│B)]		 N2a Proteome 5
Posterior Probability [P(A│B)]		 N2a Proteome 6
Posterior Probability [P(A│B)]		 OGD Proteome 1
Posterior Probability [P(A│B)]		 OGD Proteome 2
Posterior Probability [P(A│B)]		 OGD Proteome 3
Posterior Probability [P(A│B)]		 OGD Proteome 4
Posterior Probability [P(A│B)]		 ROS-GO
Posterior Probability [P(A│B)]		 Rank