The Yenepoya Research Centre (YRC), established in 2008, is a constituent unit of Yenepoya (Deemed to be University). YRC is devoted to multidisciplinary research spanning fundamental, applied, and translational research. YRC has state-of-the-art facilities and resources to foster cutting-edge research and innovation involving various stakeholders. The Centre adheres to the highest ethical standards, research integrity, follows Good Laboratory Practices, and holds ISO 17025:2017 compliance certification.The biomedical research at YRC is complemented with the Yenepoya Medical College Hospital with super-speciality departments and other constituent institutions, including those specialising in alternative medicine. The passionate research team with international experience under a collaborative and inclusive environment drives the achievements by adpating transformative emerging technologies. The academic programs offered by YRC lays a robust foundation for a promising R&D career in academia and industry, as evidenced by the global alumni presence. YRC plays a pivotal role in promoting entrepreneurship among students and faculties through the Yenepoya Technology Incubator. The research thrust areas align with the nation’s effort in achieving the United Nations Sustainable Development Goals, while addressing the challenging issues at regional and national priority areas.

Vision

To generate new knowledge towards national development through quality research integrated with the highest ethical standards

Mission
  • To engage in high quality research integrating both basic and translational research across multiple disciplines, driving towards therapeutics of human health

  • To cultivate critical thinking that can spark creativity and innovation among students and young researchers to make them leaders in the field of science and technology

33

FACULTY

45

PhD Awarded

35

PATENTS

532

PUBLICATIONS

48

EXTRAMURAL GRANTS

News and Updates

MICON 2024 - Microbes for a Sustainable Future – A National Conference on 24th and 25th January 2024.

Workshop on Fundamentals and Techniques in Proteomics - Organized by CSBMM on May 29th & 31st May 2025.

Hands on Workshop on Metabolomic Analysis: Unlocking the Power of Mass Spectrometry - Organized by CSBMM on 26th & 28th May 2025.

Science Outreach Programme on 25th May 2025.

One Day Workshop on “Grant Writing for Early-Career Researchers: Breaking into Funding” - Organized by CSBMM on 23rd & 24th May 2025.

10th Annual State-level Conference of AMBKCCON 2025- Insight into Women’s Health - organized by CBMG division, in collaboration with the Biochemistry Department on 21st May 2025.

One Day Workshop on “Single Cell and Spatial Multiomics” - Organized by CSBMM on 12th March 2025.

International Women’s Day 2025 Celebration on 8th March 2025.

National Science Day celebration on 28th February 2025.

“Microglia and Neural Rhythms In Alzheimer's disease” – A Special Guest Lecture By Dr. Chinnakkaruppan Adaikkan on 20th February 2025.

The 4th National Conference MiCON 2025 on “Divergence and surveillance of microorganisms” on 25th January 2025.

Annual Day Celebration on 31st December 2024.

The snake Feeders: Ecology, Conservation and Snake Bite Solutions – A awarness session by Mr. Rithan Bopanna KG on 20 th November 2024.

Multi-omics and System Biology Approach Reveals Mitochondrial Associated Protiens In Alzheimer’s Diseases Progression – A Special Guest Lecture by Dr.Kaushik Kumar Dey on 16 th November 2024.

Mass spectrometry-based workshop on metabolomics and data analysis conducted from 26th to 28th September 2024.

Molecular Biology Techniques – A hands on training on 3rd to 6th September 2024.

Metabolomics – A workshop conducted from 3rd to 5th September 2024.

Cardiovascular Disease in India and the establishment of CSIR longitudinal cohort by Dr. Shanthanu Sengupta- A Guest Lecture on 4th September 2024.

Financial Planning: Get early, paving way to Vikasit Bharath- A guest talk by Ms. Sandhya .T. on 29th August 2024.

Basics of Data Analytics (Hybrid Mode) – A Workshop – 26th August to 6th September 2024.

Parkinson’s Disease: Our two lines to reconnoitre the Neurobiological Basis for Pathogenesis – A special Guest talk by Dr. Phalguni Anand Alladi on 24th August 2024.

Sadbhavana Diwas Celebration by NSS Unit – 20th August 2024

Aligning Grant Proposal with Sustainable Development Goals (SDG) for Viksit Bharat – A Symposium on 10th August 2024

Felicitation to Mr. Kushalappa Gowda for achieving a world record for a 25-hour yoga marathon on 2nd August 2024.

Computer - Aided Drug Design with BIOVIA Discovery Studio – Hands on Workshop – 1st to 2nd August 2024.

Understanding Office Ergonomics and Preventive Strategies in Musculosketal Disorders – A guest talk by Mr. Satyaraja. R. on 16th July 2024.

Navigating Intramural Funding Process and Application Requirements - A Workshop on 6th Jul 2024.

Biochemical and Biophysical Characterization of a Cancer drug target-Poly (ADP-ribose) polymerase 1 – A special guest lecture by Dr. Rajakumar Eerappa on 6th July 2024.

Mansoonia – Health Screening Camp and Awareness Program on 27th and June 28th 2024.

The Astrocyte Enigma: Unravelling the mystery of alpha synuclein pathology in Parkinson’s disease – A Special Guest Lecture by Dr. Aishwarya Raj on 20th June 2024.

Beating Burnout – A Guest Talk by Dr. Ravichandra Karkal on 19th June 2024

Global Warming – Awareness Program on 11th June 2024.

Enhancing Student Centred Teaching and Assessment – Short term Faculty Development Course on 27th to 29th April 2024.

Basic Biology and Clinical Application – Flow Cytometry workshop on 14th and 15th April 2024.

Drosophila Genetic Techniques – Hands on training on 28th to 30th March 2024.

National Science Day – 2024 celebration on 28th February 2024.

BUB1: A Multifaceted Kinase and its role in DNA Damage Signalling – A Special Lecture by Dr. Shyam Nyati on 19th February 2024.

Achievements

Publications

  1. Pinto JR, Deepika Bhat K, Bose B, Sudheer Shenoy P. Irisin: muscle’s novel player in endoplasmic reticulum stress and disease. Molecular and cellular biochemistry. 2025:1-5.
  2. Petukhova AA, Borisova NE, Dubinina TV, Sannegowda LK. Biomimicking thienyl-substituted cobalt phthalocyanine with carbon nanoparticles as hybrid electrocatalyst for augmenting oxygen reduction reaction. International Journal of Hydrogen Energy. 2025;135:285-94.
  3. Sheeraz AS, Kumara BN, Pereira P, Dsilva DJ, Mohanty PS, Prasad KS. Miniaturized 3D Printed Microfluidic Polymeric?Paper Hybrid Device for Colorimetric Detection of Arsenic (III). ChemistrySelect. 2025;10(22):e00277.
  4. Mallick S, Narayana VK, Rai AB, Upadhyay SS, Prasad TS, Shenoy S, Bose B. Hematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system. The International Journal of Biochemistry & Cell Biology. 2025;184:106773.
  5. Lakshmanan MD. Stress mediators: Cancer’s double Dilemma–Navigating the error-prone path of non-homologous end joining. Medical Hypotheses. 2025 Jun 1:111683.
  6. Roy O, Ammankallu S, Narayana VK, Narayana C, Hebbar S, Adiga PK, Joshi MB, Gowda J, Kumar A, Adiga SK, Ritting M. Mass Spectrometric Analysis of Clomiphene Citrate-induced Changes in the Secretome Profile of PAX8-positive Human Fallopian Tube Secretory Epithelial Cells and Identification of Biomarkers Relevant to Reproduction and Pregnancy. Reproductive Sciences. 2025:1-9.
  7. Pallath Majeed A, Panakaje N, Thekke Veettil S, Harikumar K, Al Mujalli H, Ali Shah A, Jassim AlKubaisi N, Sameer Alnuaimi A. The impact of clinical audits on improving the effectiveness of type 2 diabetes mellitus (T2DM) CARE in primary health centers: A comprehensive pre-post analysis through multi-layered intervention [ICAE-DM CARE STUDY PROTOCOL]. Plos one. 2025;20(7):e0313664.
  8. NS S, Maske VB, Punchappady Devasya R, Rekadwad BN. Draft genome sequence of an antibiotic-resistant Heyndrickxia oleronia strain UL23-01-03 isolated from the Arabian Sea coast, Dakshina Kannada, India. Microbiology Resource Announcements. 2025:e00494-25.
  9. Biswas T, Mallick S, Sen U, Chaudhury D, Shenoy P S, Bose B. Targeting Cellular Energetics via Ferroptosis Mediated Cell Death in Resistant Colorectal Cancer Stem Cells. BioFactors. 2025;51(4):e70024.
  10. Rai PS, Shivarajashankara YM, Prajna RH, Anil R, Bhandary YP. Serum Adiponectin and Tumor Necrosis Factor-alpha in Diabetes: A Nutritional Perspective. Biomedical and Biotechnology Research Journal (BBRJ). 2025;9(3):288-93.
  11. Madkaiker MU, Prabhu R, Sharran SS, Bhandary YP, Shenoy P. Impact of COVID-19 Vaccination on Salivary Interleukin-6 and Interleukin-8 in Children: A Case-Control Study. Journal of Indian Academy of Oral Medicine and Radiology. 2025;37(3):364-8.
  12. Venkadesh A, Mathew A, Fahmeeda TK, Sonia J, Kumara BN, Sudhakara Prasad K. Paper Electrochemical Sensor Utilizing Nano Ag?Decorated Cu2O Nanoparticles for Ascorbic Acid Detection in Tablets. Analysis & Sensing. 2025;5(4):e202400118.
  13. Mandal S, Mitra A, Bose B, Shenoy P S. Quercetin and Kaempferol Mitigate Endotoxin?Induced Skeletal Muscle Wasting by Inhibiting KLF15 Expression and Restoring the Antioxidant System. The FASEB Journal. 2025;39(13):e70790.
  14. Kumara BN, Aziz RA, Kumar MS, Raghu SV, Prasad KS. Understanding photoluminescent carbon nanodots interaction with Human Corneal Epithelial Cells and Drosophila melanogaster model. Biochemical and Biophysical Research Communications. 2025:152043.
  15. Prashanth S, Kadandelu M, Raghu SV, Prasad KS, Adhikari AV. Conductive nano nickel oxide/hydroxide paper electrochemical sensor for serotonin detection in genetically engineered Drosophila. Journal of Materials Chemistry B. 2025;13(30):9112-25.
  16. D’Souza JN, Nagaraja GK, Prabhu A, Kouser S, Navada KM. Green Synthesis and Characterization of Sauropus androgynus-Mediated Ag and Ag/ZnO Nanoparticles: Enhanced Antiproliferative Activity Against MDA-MB468 Triple-Negative Breast Cancer Cells. Journal of Cluster Science. 2025;36(4):137.
  17. Biju P, Lewis S, Shenoy MM, Prabhu A, Das R, Sravani AB, Ahmed MG, Ghate V. Efficient and Sustainable Niosomes for Targeted Delivery of Luliconazole in the Treatment of Tinea Infections. Journal of Cluster Science. 2025;36(4):136.
  18. Soonu VK, Lakshmanan MD, Naresh KN, Sreejith K. Lovastatin inhibits adipocyte-associated increased proliferation, EMT and aggressiveness of breast cancer cells. Medical Oncology. 2025;42(8):313.
  19. Rai AB, Codi JA, Kotimoole CN, Ramesh P, Narayana VK, Shaji V, Prasad TS. Data-Independent Acquisition Analysis to Identify Serum Biomarkers and Neoantigens for Differentiating Colorectal Cancer from Inflammatory Bowel Diseases. Journal of Proteome Research. 2025;24(8):4166-80.
  20. Nekrakalaya B, Kotimoole CN, Arefian M, Prasad TS, Palliyath GK, Veerappa Hanumanthappa P, Pandian Ramasubramania TP, Bangalore Jayaseelan NK, Muddumadiah C, Santhappan P, Muliyar Krishna R. A Gel-Free Genome Annotation Provides Insights into the Proteome of the Oomycete Phytophthora meadii, a Disease-Causing Pathogen in Economically Important Crops. OMICS: A Journal of Integrative Biology. 2025;29(8):384-93.
  21. Muliyar Krishna R, Maruthakasi S, Arulappan J, Kasargodu Raghava L, Abdulla Abdulla S, Budhwar R, Kumar Oraon P, Das A, Prasad TS. The Genome Sequence of the Rugose Spiraling Whitefly (Aleurodicus rugioperculatus Martin): Insights on Biology of an Invasive Agricultural Insect Pest and Implications for Pest Control. OMICS: A Journal of Integrative Biology. 2025;29(8):394-403.
  22. Kim SK, Jayachandran V, Vo TS, Wijesekara I. Safety assessment of turmeric-boswellia-sesame formulation in healthy adult volunteers: An open-label prospective study. Advances in Clinical & Experimental Medicine. 2025;34(8).
  23. Gouda MM, Balaya RD, Modi PK, Kadri S, Chanderasekaran J, Balnadupete A, Bhandary YP. Impact of curcumin on the IL-17a-mediated p53-fibrinolytic system: mouse proteomics and integrated human fibrosis scRNAseq insights. Inflammation. 2025;48(4):1957-73.
  24. Shetty R, Jose J, Maliyakkal N, DS S, Johnson RP, Bandiwadekar A, Gopan G, Ugare SR, Preman NK. Micelle nanogel–based drug delivery system for lutein in ocular administration. Naunyn-Schmiedeberg's Archives of Pharmacology. 2025:1-3.
  25. Tom VV, Jose AM, Mallick S, Sasidharan A, Pawar R, Somayaji Y, Fernandes R. Current advancement of immune function paradox of tumour-infiltrating cells and their immunotherapeutic targets: a mini-review. Naunyn-Schmiedeberg's Archives of Pharmacology. 2025:1-3.
  26. Sarma A, Phukan H, Devasahayam Arokia Balaya R, Thoduvayil S, Dhandapani G, Christie SA, Prasad TS, Madanan MG. Exoproteome Profiling Reveals Increased Secretion of Adhesins and Proteases by Leptospira interrogans to Facilitate Host Colonization and Immune Modulation. ACS Omega. 2025;10(30):32728-43.
  27. Thejaswi K, Sarojini BK, Niveditha NB, Prabhu A. Multifunctional PVA/Collagen/Lignin Composite Films and Nanofibers for UV Protection, Anticancer Activity, and Sustained Drug Delivery. CHEMISTRYSELECT. 2025;10(31).
  28. Balnadupete A, Moideen FM, Varughese A, Mugaranja K, M JT, Charavu R, Bhandary Y. Beyond the pill: incrimination of nuclear factor-kappa B and their targeted phytomedicine for pulmonary fibrosis. Naunyn-Schmiedeberg's Archives of Pharmacology. 2025:1-27.
  29. Mohanto S, Ahmed MG, Bhunia A, Prabhu A. Synthesis of zinc oxide nanoparticles (ZnO NPs) via modified chemical method for potential effectiveness against SW982 cells in osteoarthritis management. Inorganic Chemistry Communications. 2025:114633.
  30. Ashwini K, Acharya R, Roopashree PG, Raghotham A, Baud S, Rao RM, Kumari NS. Molecular Basis of the therapeutic effect of Butyrate in Glioblastoma revealed by in vitro and in silico approach. Biochemical and Biophysical Research Communications. 2025; 19:152216.
  31. Babu S, Ramakrishnan K, Krishnan D, Ramesh P, Soman S, Revikumar A, Pai VR, Rehman N, Raju R. How Do Hepatocyte MicroRNAs Play a Role in Hepatitis C Virus Replication and Pathogenesis? Emerging Hypotheses and Strategies for MicroRNA Therapeutics and Drug Development. OMICS: A Journal of Integrative Biology. 2025;29(9):415-28.
  32. Kakunje A, Prabhu A, Karkal R, Pookoth KR, Kumar P, Gupta N, Priya ES, Nishad PM. Study of association between valproic acid levels, biotinidase activity and hair loss in Indian population: A cross-sectional comparative study. Indian Journal of Psychiatry. 2025;67(9):894-9.
  33. Varughese A, Balnadupete A, Moideen FM, Madambath JT, Charavu R, Mugaranja K, Sunil P, Dhivya Dharsini DM, ArunBharathi A, Bhandary YP. Tissue Factor Driven Coagulation and Inflammation in Lung Injury: Insights From In Vitro and In Vivo Models. IUBMB life. 2025;77(9):e70060.
  34. Keremane KS, Eletmany MR, Abdellah IM, Naik P, Adhikari AV. New carbazole-based symmetric double D–A type chromophores for DSSC application: Impact of di-anchoring nature on photoelectrochemical processes. Journal of Photochemistry and Photobiology A: Chemistry. 2025;466:116368.
  35. Kumara BN, Kalimuthu P, Prasad KS. Engineering and Unlocking the Potential of Photoluminescent Carbogenic Nanomaterials in Antiviral and Anticancer Therapeutic Delivery, and Regenerative Medicine. ACS Applied Bio Materials. 2025;8(9):7535-66.
  36. Kumara BN, Kalimuthu P, Prasad KS. Engineering and Unlocking the Potential of Photoluminescent Carbogenic Nanomaterials in Antiviral and Anticancer Therapeutic Delivery, and Regenerative Medicine. ACS Applied Bio Materials. 2025;8(9):7535-66.
  37. Mitra A, Chaudhury D, Rai AB, Das UN, Prasad TS, Bose B, Shenoy P S. Arachidonic Acid Protects Skeletal Muscle Against Hyperglycaemia?Induced Muscle Atrophy by Modulating Myogenesis and Regulating KLF15 Expression in C57Bl/6 Mice. The FASEB Journal. 2025;39(18):e71036.
  38. Mitra A, Chaudhury D, Rai AB, Das UN, Prasad TS, Bose B, Shenoy P S. Arachidonic Acid Protects Skeletal Muscle Against Hyperglycaemia?Induced Muscle Atrophy by Modulating Myogenesis and Regulating KLF15 Expression in C57Bl/6 Mice. The FASEB Journal. 2025;39(18):e71036.
  39. Sajwani N, Suchitha GP, Keshava Prasad TS, Dagamajalu S. Drug repurposing in oncology: a path beyond the bottleneck. Medical Oncology. 2025;42(10):443.
  40. Ramesh P, Upadhyay SS, Thomas SD, Sorake CJ, MK G, Shetty VV, Modi PK, Shetty R, Vijayakumar M, Codi JA, Prasad TS. Differentiating Gastric Cancers from Acid Peptic Diseases through Integrative Targeted Proteomics and Machine Learning Approaches. Journal of Proteome Research. 2025;24(10):5159-76.
  41. Hay SI, Ong KL, Santomauro DF, Aalipour MA, Aalruz H, Ababneh HS, Abaraogu UO, Abate BB, Abbafati C, Abbas N, Abbasifard M. Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023. The Lancet. 2025;406(10513):1873-922.
  42. Kumar KA, Nair A, Sharma S, Singh D, Yadav S, Bhimsaria D, Gupta S, Hazra S. Strategic design of a multi-tier database for class A ?-lactamase BlaC variants of M. tuberculosis: advancing the fight against antibacterial resistance. The Journal of Antibiotics. 2025;78(12):757-72.
  43. Lin SY, Hameed A, Lin TY, Young CC. Description of Fulverythrobacter ferritrahens gen. nov., sp. nov., a Siderophore-Producing Bacterium Isolated from Poultry Manure Compost and Reclassification of Caenibius fulvus and Altererythrobacter segetis as Fulverythrobacter fulvus Comb. nov. and Croceibacterium segetis Comb. nov. Current Microbiology. 2025;82(11):536.
  44. Krishnan G, Sil M, Aravind NA, Umapathy G, Datta-Roy A. Nuclear and mitochondrial genome assemblies of Indrella ampulla, a terrestrial gastropod endemic to the Western Ghats. Genome Biology and Evolution. 2025;17(11):evaf199.
  45. Ingilela AB, Sekar P, Prabhu A, Balan AS. Investigating the Role of WEDM Surface Texturing in the Degradation and Biocompatibility of Mg-Zn-Ca alloy. International Journal of Lightweight Materials and Manufacture. 2025.
  46. Magham SV, Shanavas S, Pindiprolu SS, Nagappan K, More S, Chaudhury D, Ramakkamma AR, Singh MT, Wadhwani A, Bose B, Thaggikuppe Krishnamurthy P. Targeting GSK-3? to Modulate the Wnt Pathway: A Promising Neuroprotective Strategy for Alzheimer’s Disease. Molecular Pharmaceutics. 2025;22(11):6561-74.
  47. Shastry RP, Hameed A, Banerjee S, Prabhu A, Bajire SK, Pavan SR, Dhanyashree HR, Kotimoole CN, Stothard P, Surya S, Keshava Prasad TS. Tryptic oncopeptide secreted from the gut bacterium Cronobacter malonaticus PO3 promotes colorectal cancer. Scientific Reports. 2025;15(1):9958.
  48. Rai AB, Codi JA, Suchitha GP, Hemavathi KN, Dagamajalu S, Abhinand CS, Raju R, Prasad TS. Mapping growth differentiation factor-15 (GDF15)-mediated signaling pathways in cancer: insights into its role across different cancer types. Discover Oncology. 2025;16(1):1-5.
  49. Mahadevaswamy M, Suchitha GP, Pavan SR, Vivek HK, Nithya SD, Chandan S, Prasad SK, Keshava Prasad TS, Ahmad SF, Attia SM, Dagamajalu S. Naringin attenuates angiotensin II induced cardiac hypertrophy by inhibiting carbonic anhydrase II. Scientific Reports. 2025;15(1):11789.
  50. Poojary KK, Kunhiraman JP, Madhvacharya VV, Kumari S, Krishna N, S SP, K RG, Mutalik S, Ghani NK, Kabekkodu SP, Prasad TS. Bromodomain and extraterminal protein inhibitor JQ1 induces maturation arrest and disrupts the cytoplasmic organization in mouse oocytes under in vitro conditions. Scientific Reports. 2025;15(1):13448.

Testimonials

An excellent facility with superior scope

Dr. VijayRaghavan

Secretary, DBT, New Delhi
Nice to see a bubbling group of researchers in a new upcoming research centre

Bharat Ratna Dr. C. N. R Rao

Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore
Proud to see such wonderful work at the facility and in faraway Mangalore

Dr. A. K. D’Cruz

Director-Tata Memorial Hospital, Mumbai
I was excited to see the advancement done by the institution in every aspect of medical science including latest laboratory in the premise. I pray the God that this institution will prosper and give benefit to the nation in health sector

Shri Shripad Yesso Naik

The Union Minister of AYUSH, Government of India
Wonderful facility! Research is the future to solve issues in medicine. I am very impressed with the passion of the faculty in R & D. Keep up the good work

Faizal E. Kottikollon and Shabana Faizal

Faizal Shabana Foundation, Bangalore
It is very good to see how committed you are with research

Dr. Claudio Almeida Quadros

Bahia State University, Brazil
An ideal facility positioning with cutting edge research and talented researchers right in the middle of a hospital, just what is needed for the translational research

Prof. Pauline Ford

School of Dentistry, The University of Queensland, Australia

Certifications