YRC YRC
Telephone

+91-824-2204668

Email Address

yrcoffice@yenepoya.edu.in
yrc.services@yenepoya.edu.in

Office Address

University Road, Deralakatte,
Mangalore 575018

YRC YRC

The Yenepoya Research Centre (YRC), established in 2008, is a constituent unit of Yenepoya (Deemed to be University). YRC is devoted to multidisciplinary research spanning fundamental, applied, and translational research. YRC has state-of-the-art facilities and resources to foster cutting-edge research and innovation involving various stakeholders. The Centre adheres to the highest ethical standards, research integrity, follows Good Laboratory Practices, and holds ISO 17025:2017 compliance certification.The biomedical research at YRC is complemented with the Yenepoya Medical College Hospital with super-speciality departments and other constituent institutions, including those specialising in alternative medicine. The passionate research team with international experience under a collaborative and inclusive environment drives the achievements by adpating transformative emerging technologies. The academic programs offered by YRC lays a robust foundation for a promising R&D career in academia and industry, as evidenced by the global alumni presence. YRC plays a pivotal role in promoting entrepreneurship among students and faculties through the Yenepoya Technology Incubator. The research thrust areas align with the nation’s effort in achieving the United Nations Sustainable Development Goals, while addressing the challenging issues at regional and national priority areas.

Vision

To generate new knowledge towards national development through quality research integrated with the highest ethical standards

Mission

  • To engage in high quality research integrating both basic and translational research across multiple disciplines, driving towards therapeutics of human health

  • To cultivate critical thinking that can spark creativity and innovation among students and young researchers to make them leaders in the field of science and technology

Divisions

Laboratory Services

Cancer Research and Therapeutics

Laboratory Services

Center for Systems Biology and Molecular Medicine

Laboratory Services

Division of Cell Biology and Molecular Genetics

Laboratory Services

Division of Data Analytics, Bioinformatics, and Structural Biology

Laboratory Services

Division of Microbiology and Biotechnology

Laboratory Services

Division of Neuroscience


Laboratory Services

Stem Cells and Regenerative Medicine Center

Laboratory Services

Smart Materials and Device

33

FACULTY

45

PhD Awarded

35

PATENTS

532

PUBLICATIONS

48

EXTRAMURAL GRANTS

News and Updates

MICON 2024 - Microbes for a Sustainable Future – A National Conference on 24th and 25th January 2024.

Workshop on Fundamentals and Techniques in Proteomics - Organized by CSBMM on May 29th & 31st May 2025.

Hands on Workshop on Metabolomic Analysis: Unlocking the Power of Mass Spectrometry - Organized by CSBMM on 26th & 28th May 2025.

Science Outreach Programme on 25th May 2025.

One Day Workshop on “Grant Writing for Early-Career Researchers: Breaking into Funding” - Organized by CSBMM on 23rd & 24th May 2025.

10th Annual State-level Conference of AMBKCCON 2025- Insight into Women’s Health - organized by CBMG division, in collaboration with the Biochemistry Department on 21st May 2025.

One Day Workshop on “Single Cell and Spatial Multiomics” - Organized by CSBMM on 12th March 2025.

International Women’s Day 2025 Celebration on 8th March 2025.

National Science Day celebration on 28th February 2025.

“Microglia and Neural Rhythms In Alzheimer's disease” – A Special Guest Lecture By Dr. Chinnakkaruppan Adaikkan on 20th February 2025.

The 4th National Conference MiCON 2025 on “Divergence and surveillance of microorganisms” on 25th January 2025.

Annual Day Celebration on 31st December 2024.

The snake Feeders: Ecology, Conservation and Snake Bite Solutions – A awarness session by Mr. Rithan Bopanna KG on 20 th November 2024.

Multi-omics and System Biology Approach Reveals Mitochondrial Associated Protiens In Alzheimer’s Diseases Progression – A Special Guest Lecture by Dr.Kaushik Kumar Dey on 16 th November 2024.

Mass spectrometry-based workshop on metabolomics and data analysis conducted from 26th to 28th September 2024.

Molecular Biology Techniques – A hands on training on 3rd to 6th September 2024.

Metabolomics – A workshop conducted from 3rd to 5th September 2024.

Cardiovascular Disease in India and the establishment of CSIR longitudinal cohort by Dr. Shanthanu Sengupta- A Guest Lecture on 4th September 2024.

Financial Planning: Get early, paving way to Vikasit Bharath- A guest talk by Ms. Sandhya .T. on 29th August 2024.

Basics of Data Analytics (Hybrid Mode) – A Workshop – 26th August to 6th September 2024.

Parkinson’s Disease: Our two lines to reconnoitre the Neurobiological Basis for Pathogenesis – A special Guest talk by Dr. Phalguni Anand Alladi on 24th August 2024.

Sadbhavana Diwas Celebration by NSS Unit – 20th August 2024

Aligning Grant Proposal with Sustainable Development Goals (SDG) for Viksit Bharat – A Symposium on 10th August 2024

Felicitation to Mr. Kushalappa Gowda for achieving a world record for a 25-hour yoga marathon on 2nd August 2024.

Computer - Aided Drug Design with BIOVIA Discovery Studio – Hands on Workshop – 1st to 2nd August 2024.

Understanding Office Ergonomics and Preventive Strategies in Musculosketal Disorders – A guest talk by Mr. Satyaraja. R. on 16th July 2024.

Navigating Intramural Funding Process and Application Requirements - A Workshop on 6th Jul 2024.

Biochemical and Biophysical Characterization of a Cancer drug target-Poly (ADP-ribose) polymerase 1 – A special guest lecture by Dr. Rajakumar Eerappa on 6th July 2024.

Mansoonia – Health Screening Camp and Awareness Program on 27th and June 28th 2024.

The Astrocyte Enigma: Unravelling the mystery of alpha synuclein pathology in Parkinson’s disease – A Special Guest Lecture by Dr. Aishwarya Raj on 20th June 2024.

Beating Burnout – A Guest Talk by Dr. Ravichandra Karkal on 19th June 2024

Global Warming – Awareness Program on 11th June 2024.

Enhancing Student Centred Teaching and Assessment – Short term Faculty Development Course on 27th to 29th April 2024.

Basic Biology and Clinical Application – Flow Cytometry workshop on 14th and 15th April 2024.

Drosophila Genetic Techniques – Hands on training on 28th to 30th March 2024.

National Science Day – 2024 celebration on 28th February 2024.

BUB1: A Multifaceted Kinase and its role in DNA Damage Signalling – A Special Lecture by Dr. Shyam Nyati on 19th February 2024.

Announcements

Call for PhD Admissions 2025-2026 Click

Achievements

Publications

  1. Biju P, Lewis S, Shenoy MM, Prabhu A, Das R, Sravani AB, Ahmed MG, Ghate V. Efficient and Sustainable Niosomes for Targeted Delivery of Luliconazole in the Treatment of Tinea Infections. Journal of Cluster Science. 2025;36(4):136.
  2. Soonu VK, Lakshmanan MD, Naresh KN, Sreejith K. Lovastatin inhibits adipocyte-associated increased proliferation, EMT and aggressiveness of breast cancer cells. Medical Oncology. 2025;42(8):313.
  3. Rai AB, Codi JA, Kotimoole CN, Ramesh P, Narayana VK, Shaji V, Prasad TS. Data-Independent Acquisition Analysis to Identify Serum Biomarkers and Neoantigens for Differentiating Colorectal Cancer from Inflammatory Bowel Diseases. Journal of Proteome Research. 2025;24(8):4166-80.
  4. Nekrakalaya B, Kotimoole CN, Arefian M, Prasad TS, Palliyath GK, Veerappa Hanumanthappa P, Pandian Ramasubramania TP, Bangalore Jayaseelan NK, Muddumadiah C, Santhappan P, Muliyar Krishna R. A Gel-Free Genome Annotation Provides Insights into the Proteome of the Oomycete Phytophthora meadii, a Disease-Causing Pathogen in Economically Important Crops. OMICS: A Journal of Integrative Biology. 2025;29(8):384-93.
  5. Muliyar Krishna R, Maruthakasi S, Arulappan J, Kasargodu Raghava L, Abdulla Abdulla S, Budhwar R, Kumar Oraon P, Das A, Prasad TS. The Genome Sequence of the Rugose Spiraling Whitefly (Aleurodicus rugioperculatus Martin): Insights on Biology of an Invasive Agricultural Insect Pest and Implications for Pest Control. OMICS: A Journal of Integrative Biology. 2025;29(8):394-403.
  6. Kim SK, Jayachandran V, Vo TS, Wijesekara I. Safety assessment of turmeric-boswellia-sesame formulation in healthy adult volunteers: An open-label prospective study. Advances in Clinical & Experimental Medicine. 2025;34(8).
  7. Gouda MM, Balaya RD, Modi PK, Kadri S, Chanderasekaran J, Balnadupete A, Bhandary YP. Impact of curcumin on the IL-17a-mediated p53-fibrinolytic system: mouse proteomics and integrated human fibrosis scRNAseq insights. Inflammation. 2025;48(4):1957-73.
  8. Shetty R, Jose J, Maliyakkal N, DS S, Johnson RP, Bandiwadekar A, Gopan G, Ugare SR, Preman NK. Micelle nanogel–based drug delivery system for lutein in ocular administration. Naunyn-Schmiedeberg's Archives of Pharmacology. 2025:1-3.
  9. Tom VV, Jose AM, Mallick S, Sasidharan A, Pawar R, Somayaji Y, Fernandes R. Current advancement of immune function paradox of tumour-infiltrating cells and their immunotherapeutic targets: a mini-review. Naunyn-Schmiedeberg's Archives of Pharmacology. 2025:1-3.
  10. Sarma A, Phukan H, Devasahayam Arokia Balaya R, Thoduvayil S, Dhandapani G, Christie SA, Prasad TS, Madanan MG. Exoproteome Profiling Reveals Increased Secretion of Adhesins and Proteases by Leptospira interrogans to Facilitate Host Colonization and Immune Modulation. ACS Omega. 2025;10(30):32728-43.
  11. Thejaswi K, Sarojini BK, Niveditha NB, Prabhu A. Multifunctional PVA/Collagen/Lignin Composite Films and Nanofibers for UV Protection, Anticancer Activity, and Sustained Drug Delivery. CHEMISTRYSELECT. 2025;10(31).
  12. Balnadupete A, Moideen FM, Varughese A, Mugaranja K, M JT, Charavu R, Bhandary Y. Beyond the pill: incrimination of nuclear factor-kappa B and their targeted phytomedicine for pulmonary fibrosis. Naunyn-Schmiedeberg's Archives of Pharmacology. 2025:1-27.
  13. Mohanto S, Ahmed MG, Bhunia A, Prabhu A. Synthesis of zinc oxide nanoparticles (ZnO NPs) via modified chemical method for potential effectiveness against SW982 cells in osteoarthritis management. Inorganic Chemistry Communications. 2025:114633.
  14. Ashwini K, Acharya R, Roopashree PG, Raghotham A, Baud S, Rao RM, Kumari NS. Molecular Basis of the therapeutic effect of Butyrate in Glioblastoma revealed by in vitro and in silico approach. Biochemical and Biophysical Research Communications. 2025; 19:152216.
  15. Babu S, Ramakrishnan K, Krishnan D, Ramesh P, Soman S, Revikumar A, Pai VR, Rehman N, Raju R. How Do Hepatocyte MicroRNAs Play a Role in Hepatitis C Virus Replication and Pathogenesis? Emerging Hypotheses and Strategies for MicroRNA Therapeutics and Drug Development. OMICS: A Journal of Integrative Biology. 2025;29(9):415-28.
  16. Kakunje A, Prabhu A, Karkal R, Pookoth KR, Kumar P, Gupta N, Priya ES, Nishad PM. Study of association between valproic acid levels, biotinidase activity and hair loss in Indian population: A cross-sectional comparative study. Indian Journal of Psychiatry. 2025;67(9):894-9.
  17. Varughese A, Balnadupete A, Moideen FM, Madambath JT, Charavu R, Mugaranja K, Sunil P, Dhivya Dharsini DM, ArunBharathi A, Bhandary YP. Tissue Factor Driven Coagulation and Inflammation in Lung Injury: Insights From In Vitro and In Vivo Models. IUBMB life. 2025;77(9):e70060.
  18. Keremane KS, Eletmany MR, Abdellah IM, Naik P, Adhikari AV. New carbazole-based symmetric double D–A type chromophores for DSSC application: Impact of di-anchoring nature on photoelectrochemical processes. Journal of Photochemistry and Photobiology A: Chemistry. 2025;466:116368.
  19. Kumara BN, Kalimuthu P, Prasad KS. Engineering and Unlocking the Potential of Photoluminescent Carbogenic Nanomaterials in Antiviral and Anticancer Therapeutic Delivery, and Regenerative Medicine. ACS Applied Bio Materials. 2025;8(9):7535-66.
  20. Kumara BN, Kalimuthu P, Prasad KS. Engineering and Unlocking the Potential of Photoluminescent Carbogenic Nanomaterials in Antiviral and Anticancer Therapeutic Delivery, and Regenerative Medicine. ACS Applied Bio Materials. 2025;8(9):7535-66.
  21. Mitra A, Chaudhury D, Rai AB, Das UN, Prasad TS, Bose B, Shenoy P S. Arachidonic Acid Protects Skeletal Muscle Against Hyperglycaemia?Induced Muscle Atrophy by Modulating Myogenesis and Regulating KLF15 Expression in C57Bl/6 Mice. The FASEB Journal. 2025;39(18):e71036.
  22. Mitra A, Chaudhury D, Rai AB, Das UN, Prasad TS, Bose B, Shenoy P S. Arachidonic Acid Protects Skeletal Muscle Against Hyperglycaemia?Induced Muscle Atrophy by Modulating Myogenesis and Regulating KLF15 Expression in C57Bl/6 Mice. The FASEB Journal. 2025;39(18):e71036.
  23. Sajwani N, Suchitha GP, Keshava Prasad TS, Dagamajalu S. Drug repurposing in oncology: a path beyond the bottleneck. Medical Oncology. 2025;42(10):443.
  24. Ramesh P, Upadhyay SS, Thomas SD, Sorake CJ, MK G, Shetty VV, Modi PK, Shetty R, Vijayakumar M, Codi JA, Prasad TS. Differentiating Gastric Cancers from Acid Peptic Diseases through Integrative Targeted Proteomics and Machine Learning Approaches. Journal of Proteome Research. 2025;24(10):5159-76.
  25. Hay SI, Ong KL, Santomauro DF, Aalipour MA, Aalruz H, Ababneh HS, Abaraogu UO, Abate BB, Abbafati C, Abbas N, Abbasifard M. Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023. The Lancet. 2025;406(10513):1873-922.
  26. Kumar KA, Nair A, Sharma S, Singh D, Yadav S, Bhimsaria D, Gupta S, Hazra S. Strategic design of a multi-tier database for class A ?-lactamase BlaC variants of M. tuberculosis: advancing the fight against antibacterial resistance. The Journal of Antibiotics. 2025;78(12):757-72.
  27. Lin SY, Hameed A, Lin TY, Young CC. Description of Fulverythrobacter ferritrahens gen. nov., sp. nov., a Siderophore-Producing Bacterium Isolated from Poultry Manure Compost and Reclassification of Caenibius fulvus and Altererythrobacter segetis as Fulverythrobacter fulvus Comb. nov. and Croceibacterium segetis Comb. nov. Current Microbiology. 2025;82(11):536.
  28. Krishnan G, Sil M, Aravind NA, Umapathy G, Datta-Roy A. Nuclear and mitochondrial genome assemblies of Indrella ampulla, a terrestrial gastropod endemic to the Western Ghats. Genome Biology and Evolution. 2025;17(11):evaf199.
  29. Ingilela AB, Sekar P, Prabhu A, Balan AS. Investigating the Role of WEDM Surface Texturing in the Degradation and Biocompatibility of Mg-Zn-Ca alloy. International Journal of Lightweight Materials and Manufacture. 2025.
  30. Magham SV, Shanavas S, Pindiprolu SS, Nagappan K, More S, Chaudhury D, Ramakkamma AR, Singh MT, Wadhwani A, Bose B, Thaggikuppe Krishnamurthy P. Targeting GSK-3? to Modulate the Wnt Pathway: A Promising Neuroprotective Strategy for Alzheimer’s Disease. Molecular Pharmaceutics. 2025;22(11):6561-74.
  31. Shastry RP, Hameed A, Banerjee S, Prabhu A, Bajire SK, Pavan SR, Dhanyashree HR, Kotimoole CN, Stothard P, Surya S, Keshava Prasad TS. Tryptic oncopeptide secreted from the gut bacterium Cronobacter malonaticus PO3 promotes colorectal cancer. Scientific Reports. 2025;15(1):9958.
  32. Rai AB, Codi JA, Suchitha GP, Hemavathi KN, Dagamajalu S, Abhinand CS, Raju R, Prasad TS. Mapping growth differentiation factor-15 (GDF15)-mediated signaling pathways in cancer: insights into its role across different cancer types. Discover Oncology. 2025;16(1):1-5.
  33. Mahadevaswamy M, Suchitha GP, Pavan SR, Vivek HK, Nithya SD, Chandan S, Prasad SK, Keshava Prasad TS, Ahmad SF, Attia SM, Dagamajalu S. Naringin attenuates angiotensin II induced cardiac hypertrophy by inhibiting carbonic anhydrase II. Scientific Reports. 2025;15(1):11789.
  34. Poojary KK, Kunhiraman JP, Madhvacharya VV, Kumari S, Krishna N, S SP, K RG, Mutalik S, Ghani NK, Kabekkodu SP, Prasad TS. Bromodomain and extraterminal protein inhibitor JQ1 induces maturation arrest and disrupts the cytoplasmic organization in mouse oocytes under in vitro conditions. Scientific Reports. 2025;15(1):13448.
  35. Rawat A, Antil N, Meenakshi, Deshmukh B, Rai AB, Nagar A, Kumar N, Prasad TK, Karmodiya K, Sharma P. PfPPM2 signalling regulates asexual division and sexual conversion of human malaria parasite Plasmodium falciparum. Nature Communications. 2025;16(1):4790.
  36. Suhasini PC, Shetty VV, Bhat V, Shetty PK, Roopashree PG, Rao RM, Kumari NS. CD9 knockdown inhibits cell proliferation, migration, and invasion and augments apoptosis in tongue cancer cells through regulation of the EGFR signalling pathway. Molecular Biology Reports. 2025;52(1):525.
  37. Krishna S, Sequeira JJ, Mustak MS, Das R. Mitochondrial DNA HVRII (Poly-C) and HVRIII (Poly-CA) tandem repeat variation in the Koraga population. Egyptian Journal of Medical Human Genetics. 2025;26(1):106.
  38. Rahmath NA, Lin SY, Young CC, Hameed A. Volatile dimethyl disulphide emission from Burkholderia cepacia LS-044 suppresses metabolism and budding in caspofungin-resistant Nakaseomyces glabratus NT2. Scientific Reports. 2025;15(1):23307.
  39. Palollathil A, Dagamajalu S, Ahmed M, Vijayakumar M, Prasad TS, Raju R. The network map of mucin 1 mediated signaling in cancer progression and immune modulation. Discover Oncology. 2025;16(1):1404.
  40. Subramaniyan Y, Mujeeburahiman M, Khan A, Rekha PD. Overexpression of Agr quorum sensing system in uropathogenic Staphylococcus aureus in response to simulated urinary metabolic conditions enhancing growth and virulence. Medical Microbiology and Immunology. 2025;214(1):35.
  41. Mukherjee S, Das A, Karati D, Sinha D, Chakraborty M, Mishra PK, Ahmed MG. Design and Optimization of a Model Bcs Class II Drug-Loaded Glyceryl Monostearate Nanoparticles: Antidiabetic Efficacy and Teratogenic Safety in Zebrafish. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences. 2025;95(4):811-22.
  42. Siby CE, Beary I, Das R. Unravelling the genetic and epidemiological landscape of Handigodu syndrome in Southern India. Egyptian Journal of Medical Human Genetics. 2025;26(1):138.
  43. Baliga MS, Kalaimathi A, Jagadeesh NS, Ullal C, Rajeev AG, Krishna A, Simon P, George T, Palatty PL. Role of Nurses in Cancer Education, Screening, and Detection in the Community: Narrative Review Addressing the Existing Lacunae and Scope in India. Indian Journal of Medical and Paediatric Oncology. 2025.
  44. Naik P, Abdellah IM, Abdel?Shakour M, Keremane KS, Adhikari AV. Enhancing the Photoelectrochemical Performance of Ru (II)?Sensitized Dye?Sensitized Solar Cells Using Cyanopyridine?Based Cosensitizers. Energy Technology. 2025;13(12):2500294.
  45. GV YD, Pinto JR, Bose B, Shenoy S. Sulphated polysaccharides and biomaterials: Steering stem cell fate. Carbohydrate Polymers. 2025;369:124308.
  46. Hameed A, Young CC, Suchithra KV, Prabhu A, Dhanyashree HR, Shastry RP. Pantoea piersonii IIIF1SW-P2T triggers cytotoxicity through L-asparaginase-driven ammonium secretion and colonizes reproductive tract of Caenorhabditis elegans. Scientific Reports. 2025;15(1):35295.
  47. Karouia F, de Oliveira LC, Hameed A, Simpson A, Singh N, Rekha PD, Mason CE, Venkateswaran K. Genomic characterization of Microbacterium meiriae sp. nov., a novel bacterium isolated from the International Space Station. Scientific Reports. 2025;15(1):35770.
  48. Kumar P, Anne G, Ramesh S, Kudva SA, Ramesh MR, Doddamani M, Prabhu A, Sahu S. High-pressure torsion of biodegradable Mg? Zn? Mn alloy and investigate mechanical and corrosion behaviour. Scientific Reports. 2025;15(1):36168.
  49. Tejaswi L, Ramesh P, Aditya S, Raju R, Prasad TS. Computational neoantigen prediction for cancer immunotherapy. Genes & Immunity. 2025:1-8.
  50. Narayana S, Ahmed MG, Prabhu A, Paul K, Gowda BJ. Synthesis, Characterization, and In Vitro Evaluation of Anticancer Activity of Bevacizumab Encapsulated PLGA Nanoparticles on Ovarian Carcinoma Cells. Journal of Pharmaceutical Innovation. 2025;20(6):246.

Testimonials

An excellent facility with superior scope

Dr. VijayRaghavan

Secretary, DBT, New Delhi
Nice to see a bubbling group of researchers in a new upcoming research centre

Bharat Ratna Dr. C. N. R Rao

Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore
Proud to see such wonderful work at the facility and in faraway Mangalore

Dr. A. K. D’Cruz

Director-Tata Memorial Hospital, Mumbai
I was excited to see the advancement done by the institution in every aspect of medical science including latest laboratory in the premise. I pray the God that this institution will prosper and give benefit to the nation in health sector

Shri Shripad Yesso Naik

The Union Minister of AYUSH, Government of India
Wonderful facility! Research is the future to solve issues in medicine. I am very impressed with the passion of the faculty in R & D. Keep up the good work

Faizal E. Kottikollon and Shabana Faizal

Faizal Shabana Foundation, Bangalore
It is very good to see how committed you are with research

Dr. Claudio Almeida Quadros

Bahia State University, Brazil
An ideal facility positioning with cutting edge research and talented researchers right in the middle of a hospital, just what is needed for the translational research

Prof. Pauline Ford

School of Dentistry, The University of Queensland, Australia

Certifications